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Synlett 1998; 1998(4): 389-390
DOI: 10.1055/s-1998-3132
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Practical Synthesis of threo-(S,2S)- and erythro-(1R,2S)-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) from l-Serine

Atsushi Nishida* , Hiroshi Sorimachi, Mie Iwaida, Miyako Matsumizu, Tomohiko Kawate, Masako Nakagawa
  • *Faculty of Pharmaceutical Sciences, Chiba University, Yagoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan; Fax 81-43-290-3021; E-mail: nakagawa@p.chiba.u.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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Both l-threo- and d-erythro-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (PPMP) were synthesized stereoselectively from l-serine.

l-threo-PPMP - d-erythro-PPMP - l-serine - anti-malarial drug - sphingomyelinase inhibitor

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