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Synthesis 1998; 1998(4): 405-408
DOI: 10.1055/s-1998-2049
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Synthesis of 2-[(Benzyloxycarbonylamino)phenylmethyl]-1,3,2-benzodioxaphosphole 2-Oxides

Qing Dai* , Ruyu Chen, Chunxiang Zhang, Zhun Liu
  • *Institute and State's key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China; Fax + 86(22)23 50 34 38; E-mail: qingdai@mail.zlnet.co.cn
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Publication Date:
31 December 2000 (online)

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A simple method for the preparation of 2-[(benzyloxycarbonylamino)phenylmethyl]-1,3,2-benzodioxaphosphole 2-oxides in high yield consists of the three-component reaction of benzyl carbamate, an aromatic aldehyde and 2-chloro-1,3,2-benzodioxaphosphole in acetyl chloride or anhydrous benzene. Different reaction conditions have been investigated and the reaction mechanisms are suggested.

cyclic α-aminophosphonate - phosphonopeptide - mechanism - microwave irradiation