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Synlett 1998; 1998(12): 1308-1310
DOI: 10.1055/s-1998-1983
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New Synthetic Route to the Highly Strained Cores of C-1027 and Neocarzinostatin Chromophores

I. Sato* , K. Toyama, T. Kikuchi, M. Hirama
  • *Department of Chemistry, Graduate School of Science, Tohoku University, and CREST, Japan Science and Technology Corporation (JST), Sendai, 980-8578, Japan; Fax + 81-22-217-6566; E-mail: hirama@ykbsc.chem.tohoku.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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Efficient construction of the bicyclo[7.3.0]dodecenediyne cores of chromophore of C-1027 (1) and neocarzinostatin (2) was obtained via the C-C bond formation at C5-C6 using the LiN(SiMe3)2/CeCl3-mediated acetylide-aldehyde condensation reaction.

C-1027 - neocarzinostatin - lithium hexamethyldisilazide - cerium trichloride - acetylide-aldehyde condensation

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