Synlett 1998; 1998(9): 1022-1024
DOI: 10.1055/s-1998-1852
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Synthetic Studies on Bengazoles of Marine Sponge Origin. Synthesis of the Core Bis-oxazole Fragments

Pabba Chittari* , Yasumasa Hamada, Takayuki Shioiri
  • *Faculty of Pharmaceutical Sciences, Nagoya City University, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan; Fax + 81-52-834-4172; E-mail:
Further Information

Publication History

Publication Date:
31 December 2000 (online)

The core bis-oxazole fragment 3 was constructed by the coupling of the aldehyde (6) with the lithiated oxazoles (7), oxidation of the resulting bis-oxazolyl methanol (11), followed by the asymmetric reduction with (R)-(+)-BINAL-H as key steps. Preparation of another bis-oxazole fragment (4) was accomplished by the Barton-McCombie radical deoxygenation reaction of 11.