SmI2-Mediated Reduction of α-Functionalised Amides: Highly Enantiospecific Access to an Atropisomeric Amide
31.Dezember 2000 (online)
SmI2 or SmI2-LiCl mixtures can be used to reduce α-functionalised amides in yields of up to 85% depending upon the amide structure. The method has been applied to the synthesis of an atropisomeric anilide system in highly enantioenriched form, starting with (S)-O-acetyl lactic acid.
samarium iodide - reduction - amide - atropisomer