A Convenient Conversion of α-Aminoacids into NH-Boc Protected α-Aminoketones via Imidazolides
31 December 2000 (online)
Imidazolides obtained from natural α-aminoacids react with a twofold excess of Grignard reagents to afford in satisfactory to good yields the corresponding NH-Boc protected α-aminoketones. Under optimized conditions the reaction with phenyl- and n-pentylmagnesium bromide required the addition of catalytic amounts of Cu(I)-salt which turned out to be unnecessary in the case of Buchi's Grignard.
α-aminoacids - imidazolides - Grignard reagents - Cu(I)-catalysis - α-aminoketones