Synthesis of Spiro-2-oxazolines
31 December 2000 (online)
Several spiro-2-oxazolines were synthesized by treatment of 2-benzoylamino-3-chloropropenoic acid with a series of aromatic and heteroaromatic diamines. Alkylation of these compounds took place on the lactam nitrogen of the 3,4-dihydropyrazin-2(1H)-one part of the spiro systems.
spiro-2-oxazolines - fused 3,4-dihydropyrazin-2(1H)-ones - cyclization - N-alkylation