Directed Palladium-Catalyzed Cascade Cyclization as an Approach to trans- and cis-Hexahydro-1H-benz[f]indenes
31 December 2000 (online)
The hydrogenation of the acetylenic substrate 6 followed by a palladium-catalyzed cascade bis-cyclization process led to a trans-hexahydro-1H-benz[f]indene. By changing the order of the two preceding steps, only the cis-hexahydro-1H-benz[f]indene structure was obtained.
Wacker-type reaction - palladium - trans-hexahydro-1H-benz[f]indene - cis-hexahydro-1H-benz[f]indene