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Synlett 1998; 1998(7): 727-728
DOI: 10.1055/s-1998-1776
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Chiral 2-(1-Dimethylaminoethyl)ferrocenecarbaldehyde as an Effective Catalyst for Asymmetric Alkylation of Aldehydes with Dialkylzinc

Shin-ichi Fukuzawa* , Hirohisa Kato
  • *Department of Applied Chemistry, Chuo University, Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan
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Publication Date:
31 December 2000 (online)

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The chiral ferrocenecarbaldehyde bearing an amino group was used as a ligand of diethylzinc in the asymmetric alkylation of aldehydes. It effectively catalyzed the reaction with either aromatic, straight chain or branched aliphatic aldehydes to afford chiral alcohols in good yields with high enantiomeric excess (up to 93% ee).

ferrocenecarbaldehyde - diethylzinc - ethylation