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Synlett 1998; 1998(7): 748-750
DOI: 10.1055/s-1998-1772
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Synthesis of Highly Functionalized Polycyclics via Pd-Catalyzed Intramolecular Coupling of Aryl/Vinylic Halides, Non-conjugated Dienes and Nucleophiles

Xiaojun Han* , Richard C. Larock
  • *Department of Chemistry, Iowa State University, Ames, Iowa 50011, U.S.A.; Fax (515)-2 94-01 05; E-mail: larock@iastate.edu
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Publication History

Publication Date:
31 December 2000 (online)

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Aryl and vinylic iodides bearing a 2,5-cyclohexadienyl moiety readily undergo sequential intramolecular/intermolecular Pd-catalyzed cross-coupling with carbon and heteroatom nucleophiles to produce a wide variety of diastereomerically pure polycyclic products in good to excellent yields.

polycyclic hydrocarbons - palladium catalysis - π-allylpalladium - cross-coupling

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