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Synlett 1998; 1998(7): 797-800
DOI: 10.1055/s-1998-1761
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Stereoselective Synthesis of Hydroxylated Indolizidines via (-)-Sparteine-Mediated Kinetic Resolution Coupled with Intramolecular Carbolithiation

Michael J. Woltering* , Roland Fröhlich, Birgit Wibbeling, Dieter Hoppe
  • *Organisch-Chemisches Institut der Universität Münster, Corrensstr. 40, D-48149 Münster, Germany; Fax +49(251) 8 33-97 72
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Publikationsdatum:
31. Dezember 2000 (online)

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Enantioenriched 1-oxy-2-benzyl-substituted indolizidines with functionalized side chains were easily prepared from racemic 2-(carbamoyloxy)methyl-N-cinnamylpiperidine by (-)-sparteine-mediated one-step kinetic resolution and intramolecular carbolithiation.

-sparteine - kinetic resolution - enantioselective lithiation - carbolithiation - indolizidines