Download PDF
Synlett 1998; 1998(6): 637-639
DOI: 10.1055/s-1998-1729
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Rapid Synthesis of Matrix Metalloproteinase Inhibitors via Ugi Four-Component Condensation

Christopher D. Floyd* , Laura A. Harnett, Andrew Miller, Sanjay Patel, Lydia Saroglou, Mark Whittaker
  • *British Biotech Pharmaceuticals Ltd, Watlington Rd, Oxford, OX4 5LY; Fax +(0)18 65-78 08 14; E-mail: whittaker@britbio.co.uk
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

By employing ammonia, together with a mono succinate ester, an aldehyde and an isonitrile in the Ugi four-component condensation the basic structure of pseudopeptide succinyl matrix metalloproteinase inhibitors is constructed in a single step. Deprotection of the ester provides the carboxylic acid zinc(II) binding group required for biological activity.

Ugi - combinatorial - matrix metalloproteinase - MMP - ammonia - isonitrile

      >