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Synlett 1998; 1998(5): 552-553
DOI: 10.1055/s-1998-1699
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Synthesis of the Bicyclo[4.4.1]decenone Core of CP-225,917 and CP-263,114

Alan Armstrong* , Trevor J. Critchley, Andrew A. Mortlock
  • *Department of Chemistry, University of Nottingham, Nottingham NG7 2 RD, UK; Fax + 44 115 951 35 64; E-mail: Alan.Armstrong@nottingham.ac.uk
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Publication History

Publication Date:
31 December 2000 (online)

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The bicyclo[4.3.1]decenone core of the ras-farnesyl protein transferase inhibitors CP-225,917 and CP-263,114 is prepared in 6 steps from cyclohexanone. The key step is an intramolecular Mukaiyama aldol reaction.

CP-225,917 - CP-263,114 - anti-Bredt - bicyclo[4.3.1]decenone - Mukaiyama aldol

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