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Synlett 1998; 1998(5): 507-509
DOI: 10.1055/s-1998-1694
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A Formal Synthesis of (-)-α-Kainic Acid

Janine Cossy* , Manuel Cases, Domingo Gomez Pardo
  • *Laboratoire de Chimie Organique, Associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France; Fax 33.1.40.79.44.25; E-mail: janine.cossy@espci.fr
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Publication Date:
31 December 2000 (online)

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The formal synthesis of (-)-α-kainic acid was achieved from L-pyroglutamic acid. The C-4 substituent of the pyrrolidine ring was introduced by using a ketyl radical cyclization on an enecarbamate.

(-)-α-kainic acid - radical - cyclization - synthesis - L-pyroglutamic acid