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Synlett 1998; 1998(4): 369-370
DOI: 10.1055/s-1998-1676
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Indium Trifluoride - A Lewis Acid Catalyst For The Addition Of TMSCN To Aldehydes In Water

Teck-Peng Loh* , Kai-Chen Xu, Diana Sook-Chiang Ho, Keng-Yeow Sim
  • *Department of Chemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 11 92 60; Fax (65)779 16 91; E-mail: chmlohtp@nus.edu.sg
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Publication Date:
31 December 2000 (online)

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Indium trifluoride promoted chemoselective additions of TMSCN to various aldehydes in water gave the respective cyanohydrins in good yields.

indium trifluoride - trimethylsilyl cyanide - aldehydes - cyanohydrins - water