Download PDF
Synlett 1998; 1998(4): 383-384
DOI: 10.1055/s-1998-1657
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Efficient Synthesis of N,N-Disubstituted 5-Aminothiophene-2-carboxaldehydes by Nucleophilic Aromatic Substitution in Water

Damien Prim* , Gilbert Kirsch, Jean-François Nicoud
  • *Groupe de Synthèse Organique et Hétérocyclique, Laboratoire de Chimie Organique, Université de Metz, Ile du Saulcy, F-57045 Metz Sedex, France; Fax Int-33 3 87 31 53 33; E-mail: prim@sciences.univ-metz.fr
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

We have developed the first synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to the corresponding imines or amino derivatives respectively.

aminothiophenes - nucleophilic aromatic substitution - aqueous solution

      >