Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml
Synlett 1998; 1998(3): 263-264
DOI: 10.1055/s-1998-1625
DOI: 10.1055/s-1998-1625
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved.
This journal, including all individual contributions and illustrations published therein,
is legally protected by copyright for the duration of the copyright period. Any use,
exploitation or commercialization outside the narrow limits set by copyright legislation,
without the publisher's consent, is illegal and liable to criminal prosecution. This
applies in particular to photostat reproduction, copying, cyclostyling, mimeographing
or duplication of any kind, translating, preparation of microfilms, and electronic
data processing and storage.An Efficient and Facile Synthesis of Novel 3-Benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines
Further Information
Publication History
Publication Date:
31 December 2000 (online)

The condensation of 1-aryl-2-dimethylaminomethylprop-2-en-1-ones 4 with 2-aminopyridines 5 gives rise to the 3-benzoyl-3,4-dihydro-2H-pyrido[1,2-a]pyrimidines 3. The reaction is initiated by addition of the pyridine amino group to the enone double bond, followed by deamination and ring closure to give the anellated pyrimidine ring system, which is an excellent precursor for the synthesis of pharmacological active compounds.
1-arylprop-2-en-1-ones - Mannich salts - deamination - pyrido[1,2-a]pyrimidines