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Synlett 1998; 1998(2): 137-138
DOI: 10.1055/s-1998-1617
DOI: 10.1055/s-1998-1617
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Novel Asymmetric Synthesis of an Indolizidine Alkaloid, (+)-Lentiginosine Employing Highly Stereoselective Hydrogenation of α-Hydroxypyrrolidine
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Publication History
Publication Date:
31 December 2000 (online)
An efficient and novel process is described for the asymmetric synthesis of a (1S,2S,8aS)-dihydroxyindolizidine alkaloid, (+)-lentiginosine in which the asymmetric deoxygenation of the quaternary α-hydroxypyrrolidine derivative derived from D-xylose is used as a key step.
indolizidine alkaloid - (+)-lentiginosine - deoxygenation - α-hydroxypyrrolidine - xylose