Synlett 1998; 1998(2): 209-211
DOI: 10.1055/s-1998-1601
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A Mild, Efficient, and Selective Method for the Desilylation of More Common Trialkylsilyl Ethers by Cerium(III) Chloride Heptahydrate and Sodium Iodide in Acetonitrile

Giuseppe Bartoli* , Marcella Bosco, Enrico Marcantoni, Letizia Sambri, Elisabetta Torregiani
  • *Dipartimento di Scienze Chimiche, via S. Agostino 1, I-62032 Camerino (MC), Italy; Fax 39 737 637345; E-mail:
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Treatment of trialkylsilyl ethers with cerium(III) chloride heptahydrate and sodium iodide in acetonitrile provides a simple, convenient, and chemoselective process for desilylation, and the parent alcohol was obtained in high yield. The trialkylsilyl ethers have been cleaved selectively in the presence of acetate, benzyl and tetrahydropyranyl ethers.