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Synlett 1998; 1998(1): 90-92
DOI: 10.1055/s-1998-1563
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Synthesis and Radical Cyclization of 2-Allylamino-3-chloropropylphenyl Sulfones to 2,4-Disubstituted Pyrrolidines

Riccardo Giovannini* , Marino Petrini
  • *Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino, 1, I-62032 Camerino, Italy
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Publikationsdatum:
31. Dezember 2000 (online)

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Allylic and propargylic amines give a chemoselective conjugate addition to 3-chlorovinyl sulfones under appropriate conditions. The resulting allylamino sulfones are cyclized using tributyltin hydride to afford 2,4-disubstituted pyrrolidines in satisfactory yield.

vinyl sulfones - allylic amines - conjugate addition - radical cyclization - pyrrolidines