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Synlett 1997; 1997(10): 1153-1154
DOI: 10.1055/s-1997-990
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Lewis Acid-Catalyzed Deprotection of p-Methoxybenzyl Ether

Abderrahim Bouzide, Gilles Sauvé*
  • *Institut Armand-Frappier, 531 boul. de Prairies, Laval, Québec, Canada H7N 4Z3, Fax: (514) 686-5619; E-mail: sauveg@accent.net
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Publication History

Publication Date:
31 December 2000 (online)

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The p-methoxybenzyl protecting group was readily removed from alcohols and phenols using catalytic amounts of AlCl3 or SnCl2•2H2O in the presence of EtSH at room temperature. Under these mild conditions other protecting groups such as methyl and benzyl ethers, p-nitrobenzoyl esters, TBDPS ethers and isopropylidene acetal were unchanged.

p-methoxybenzyl ether - aryl PMB ether - Lewis acid - deprotection

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