PDF herunterladen
Synlett 1997; 1997(8): 983-985
DOI: 10.1055/s-1997-972
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

Takeshi Sugai, Keiji Hamada, Tomohiro Akeboshi, Hajime Ikeda, Hiromichi Ohta*
  • *Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama 223, Japan, Fax 81 45 563 5967; sugai@chem.keio.ac.jp
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subsequent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

Yamadazyma farinosa - Pseudomonas lipase - enantioselective reduction - kinetic resolution - (R)-5-hexanolide

      >