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Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide
31 December 2000 (online)
Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subsequent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.
Yamadazyma farinosa - Pseudomonas lipase - enantioselective reduction - kinetic resolution - (R)-5-hexanolide