Enantiospecific Synthesis of the 14-Memberes Diene Unit of methyl Sarcophytoate
31. Dezember 2000 (online)
The enantiospecific synthesis of the 14-membered diene unit of methyl sarcophytoate has been achieved by using the Sharpless asymmetric epoxidation, the aldol reaction, the oxy-Michael addition, and the modified Ito-Kodama cyclization as the key steps. All the carbon skeleton was derived from geraniol only.
methyl sarcophytoate - Sharpless asymmetric epoxidation - aldol reaction - oxy-Michael addition - Ito-Kodama cyclization