Synlett 1997; 1997(8): 907-908
DOI: 10.1055/s-1997-961
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Chemoselective Trifluoromethylation of Methyl Esters Using an Et3GeNa/C6H5SCF3 Combination: Efficient Synthesis of Trifluoromethyl Ketones

Yasuo Yokoyama* , Kunio Mochida1
  • *Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

Various trifluoromethyl ketones were synthesized from the corresponding methyl esters by effective nucleophilic trifluoromethylation using an Et3GeNa/C6H5SCF3 combination. This trifluoromethylation proceeded chemoselectively. When, cyclohexyl, i-propyl and t-butyl esters coexisted in the reaction system, only the methyl ester was easily transformed to the desired compounds in excellent yield. Furthermore, some protective groups were remained under this reaction condition.