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Novel Parham-type Cycloacylations of 1H-Pyrazole-1-alkanoic Acids
31 December 2000 (online)
Exposure of 1H-pyrazole-1-alkanoic acids to two equivalents of n-butyllithium affords the corresponding cyclic ketones via a Parham-type cyclization process. Although yields are modest, this procedure represents a simple and direct intramolecular acylation of a non-nucleophilic pyrazole carbon.
cycloacylation - anionic - Parham - pyrazole - lithiation