Synlett 1997; 1997(8): 989-991
DOI: 10.1055/s-1997-951
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A Convenient Procedure for the Reduction of Esters, Carboxylic Acids, Ketones and Aldehydes using Tetrabutylammonium Fluoride (or Triton® B) and Polymethylhydrosiloxane

Mark D. Drew, Nicholas J. Lawrence* , David Fontaine, Lakhdar Sehkri, Stephen A. Bowles, William Watson
  • *Dept. of Chemistry, UMIST, PO Box 88, Manchester, M60 1QD, UK; Email: [email protected]
Further Information

Publication History

Publication Date:
31 December 2000 (online)

A range of carboxylic esters and acids have been converted efficiently to the corresponding alcohols with polymethylhydrosiloxane in the presence of catalytic tetrabutylammonium fluoride. The reduction of ketones and aldehydes with PMHS and other alkoxysilanes in the presence of TBAF or benzyltrimethylammonium hydroxide is also described.