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Mild and Regiospecific Phosphorylation of Nucleosides
31 December 2000 (online)
Nucleosides are reported to be conveniently phosphorylated by diphenylphosphate previously activated with a triarylphosphine- I2 complex. The reaction is characterised by mild conditions, high yields, easy work-up and purification of the final product. The activation of the phosphorylating agent, unlike Mitsunobu reaction, enables to avoid the usual inversion of configuration at C-3'.
phosphorylation - diphenylphosphate - nucleosides - phosphine - esterification