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Reaction of Trimethylsilyl Benzhydryl Ethers with Methyl N-(Trimethylsilyl)pyroglutamate: an Easy and Rapid N-Alkylation
31 December 2000 (online)
In the presence of a small amount of catalyst (mainly triflic acid), methyl N-(trimethylsilyl)pyroglutamate quickly reacts with benzhydryl chlorides or preferentially with trimethylsilyl benzhydryl ethers to give methyl N-(benzhydryl)pyroglutamates in nearly quantitative isolated yields.
methyl N-(trimethylsilyl)pyroglutamate - benzhydryl silyl ethers - N-alkylation