Biocatalysis in Organic Synthesis. 9. Highly Enantioselective Kinetic Resolution of Secondary Alcohols Catalyzed by Acylase.1

Juan Faraldos; Elisa Arroyo; Bernardo Herradón

doi:10.1055/s-1997-796

Synlett 1997; 1997(4): 367-370
DOI: 10.1055/s-1997-796

letter

© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Biocatalysis in Organic Synthesis. 9. Highly Enantioselective Kinetic Resolution of Secondary Alcohols Catalyzed by Acylase.¹

Juan Faraldos, Elisa Arroyo, Bernardo Herradón^*

^*Instituto de Química Orgánica General, C. S. I. C., Juan de la Cierva 3, 28006 Madrid, Spain

Abstract

PDF Download All articles of this category

A new catalytic activity of the enzyme acylase I (AA-I) from Aspergillus species has been found. Although this enzyme had previously been used only in the hydrolysis of N-acylamino acids, we have found that it is a highly efficient catalyst for transesterifications using vinyl esters as acyl donors. The method has been applied to the kinetic resolution of a variety of secondary alcohols.

acylase - transesterification - kinetic resolution - acylating agent - solvent effect

PDF (322 kb)