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Synlett 1997; 1997(3): 263-264
DOI: 10.1055/s-1997-772
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© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Versatile Route to 2-Arylmethyl-1,2,4-oxadiazolidine-3,5-diones via Regiospecific Alkylation of 1,2,4-Oxadiazolidine-3,5-dione

Barrie C.C. Cantello, Susan C. Connor1 , David K. Dean2 , Richard M. Hindley
  • 1Department of Analytical Sciences, SmithKline Beecham Pharmaceuticals, Great Burgh, Epsom, Surrey, KT18 5XQ, UK
  • 2Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Great Burgh, Epsom, Surrey, KT18 5XQ, UK; E-mail: David_K_Dean@sbphrd.com
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Publikationsdatum:
31. Dezember 2000 (online)

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2-Arylmethyl-1,2,4-oxadiazolidine-3,5-diones can be prepared in a single step by the regiospecific alkylation of 1,2,4-oxadiazolidine-3,5-dione with substituted benzyl halides.

bioisostere - insulin sensitiser - 1,2,4-oxadiazolidine-3,5-dione - regiospecific alkylation - thiazolidinedione

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