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Synlett 1997; 1997(SI): 467-468
DOI: 10.1055/s-1997-6141
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Asymmetric Hydrogenation of Cyclic α,β-Unsaturated Ketones to Chiral Allylic Alcohols

Takeshi Ohkuma, Hideyuki Ikehira, Takao Ikariya, Ryoji Noyori*
  • *ERATO Molecular Catalysis Project, Research Development Corporation of Japan, 1247 Yachigusa, Yakusa-cho, Toyota 470-03, Japan, FAX +81-52-783-4177; E-mail noyori@chem3.chem.nagoya-u.ac.jp
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Publication Date:
31 December 2000 (online)

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The Ru(II)-BINAP-1,2-diphenylethylenediamine combined catalyst system effects asymmetric hydrogenation of certain cyclic enones in 2-propanol containing KOH with a substrate/catalyst molar ratio of 250 to 2500. The hydrogenation occurs selectively at the C=O function with excellent enantio- or diastereoselectivity.

asymmetric hydrogenation - BINAP - chiral allylic alcohol - chiral - 1,2-diamine - α,β-unsaturated ketone

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