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Synlett 1997; 1997(10): 1179-1180
DOI: 10.1055/s-1997-5791
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Synthesis of Chiral Bicyclic Lactams Using Ring Closure Metathesis: Synthesis of (-)-Coniceine and (S)-Pyrrolam A

Mitsuhiro Arisawa, Emiko Takezawa, Atsushi Nishida, Miwako Mori1 , Masako Nakagawa2
  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, 060 Sapporo, Japan
  • 2Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi 263, Japan
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Publication Date:
31 December 2000 (online)

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Chiral (-)-coniceine and (S)-pyrrolam A were synthesized from dienes prepared from L-proline by ring closure metathesis.

ring closure metathesis - (-)-coniceine - (S)-pyrrolam A - ruthenium carbene complex - L-proline