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Synlett 1997; 1997(7): 809-811
DOI: 10.1055/s-1997-5767
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Novel Regioselective Glycosylations for the Convergent and Chemoselective Assembly of Oligosaccharides

Geert-Jan Boons* , Tong Zhu
  • *School of Chemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
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Publication History

Publication Date:
31 December 2000 (online)

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A novel convergent chemoselective glycosylation methodology based on differences in reactivity between hydroxyl groups of a glycosyl donor and an acceptor was established. A series of di- and trisaccharides were synthesized in good to excellent yields which can be employed as acceptors in a subsequent glycosylation without the need to perform protecting group interconversions. The effectiveness of this methodology has been demonstrated in a highly convergent one-pot multi-step glycosylation yielding 1-4 and 1-6 linked tetra- and hexasaccharide.

chemoselective - glycosylation - oligosaccharides - thioglycosides

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