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Synlett 1997; 1997(7): 797-798
DOI: 10.1055/s-1997-5760
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Diazo Esters Addition to Trifluoropyruvamides: New Access to Highly Functionalized Trifluoromethyl Epoxides and Diazo Compounds

Laurent El Kaim* , Cyril Ollivier
  • *Laboratoire Réacteurs et Processus, Ecole Nationale Supérieure de Techniques Avancées, 32 boulevard Victor, 75015 Paris, France, Fax: 33.01.45.52.55.87; email: elkaim@ensta.fr
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Publication History

Publication Date:
31 December 2000 (online)

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Trifluoropyruvamides in their hydrated form readily react with diazo esters affording new trifluoromethyl epoxides. Activating the pyruvamide with trifluoroacetic anhydride leads to a complete change in selectivity with the formation of a new diazo compound.

fluoro compounds - epoxides - diazo compounds - stereoselectivity

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