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Synlett 1997; 1997(7): 824-826
DOI: 10.1055/s-1997-5757
DOI: 10.1055/s-1997-5757
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© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved.
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data processing and storage.Towards a Synthesis of Epothilone A: Rapid Assembly of the C1-C6 and C7-C12 Fragments
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Publication History
Publication Date:
31 December 2000 (online)
A very short 4-step synthesis of the C1-C6 and C7-C12 fragments 3 and 4 of epothilone A (1a), starting from bornane-10,2-sultam 5, was achieved in 77% and 56% overall yield respectively.
epothilone - taxol - microtubules - acetate-aldol - bornanesultam