Download PDF
Synthesis 1997; 1997(12): 1425-1428
DOI: 10.1055/s-1997-1377
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 5-Substituted Quinolin-8-ols

Yoshiharu Nakano* , Dai Imai
  • *Faculty of Science, Ibaraki University, Bunkyo 2-1-1, Mito, 310 Japan, Fax +81(29)2288406; E-mail: nyoshi@mito.ipc.ibaraki.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A new preparative procedure for 5-aryl- or 5-decylquinolin-8-ols was developed. The key step of the procedure is the cross coupling of 8-benzyloxy-5-bromoquinoline with arylboronic acid or 9-decyl-9-borabicyclo[3.3.1]nonane (Suzuki reaction). Deprotection of the benzyloxy group was accomplished successfully by Pd/C catalyzed hydrogen transfer from cyclohexa-1,4-diene.

Preparation of 5-aryl- or 5-decyl-quinolin-8-ols from 8-benzyloxy-5-bromoquinoline

      >