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Synthesis 1997; 1997(11): 1255-1257
DOI: 10.1055/s-1997-1349
short paper
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Convenient and Versatile Synthetic Methods for Furazano[3,4-d]pyrimidines

Magoichi Sako1 , Souichi Oda2 , Kosaku Hirota2 , George P. Beardsley3
  • 1Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502, Japan, Fax +81(58)237-5979; E-mail: sako@gifu-pu.ac.jp
  • 2Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502, Japan
  • 3Department of Pediatrics & Pharmacology, School of Medicine, Yale University, New Haven, Connecticut 06520-8064, USA
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Publication History

Publication Date:
31 December 2000 (online)

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Treatment of the readily available 6-amino-5-nitrosopyrimidines with a slight excess of iodobenzene diacetate or N-iodosuccinimide in anhydrous DMF containing three equivalents of lithium hydride at ambient temperature resulted in the smooth and versatile formation of the corresponding furazano[3,4-d]pyrimidines, which are useful intermediates for the preparation of biologically interesting fused pyrimidines.

oxidative cyclization - 6-amino-5-nitrosopyrimidines - iodosylbenzene diacetate - N-idosuccinimide - furazanopyrimidines

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