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Synthesis 1997; 1997(8): 871-873
DOI: 10.1055/s-1997-1284
short paper
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An Expedient Synthesis of 3-Amino-1,2-benzisothiazoles

Toshio Nakamura* , Hideo Nagata, Masayuki Muto, Ikutaro Saji
  • *Sumitomo Pharmaceuticals Research Center, 1-8, Kasugadenaka 3-chome, Konohana-ku, Osaka 554, Japan
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Publication History

Publication Date:
31 December 2000 (online)

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3-Amino-1,2-benzisothiazoles 3a-h were synthesized in satisfactory yields under mild conditions by reaction of 2,2'-dithiobis(benzonitrile) (2) with several secondary amines and subsequent oxidation.

3-amino-1,2-benzisothiazole - isothiazole ring formation - o-amidinobenzenethiol - Grignard reagent - CuCl2

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