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Synthesis 1997; 1997(4): 461-464
DOI: 10.1055/s-1997-1204
DOI: 10.1055/s-1997-1204
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data processing and storage.An Effective Synthesis of 2-Trifluoromethyl- or 2-(1,1-Difluoroalkyl)thiophenes
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Publication History
Publication Date:
31 December 2000 (online)
Various thiophenecarboxylates carrying a 2-trifluoromethyl, 2-(1,1-difluoroalkyl) or 2-polyfluoroalkyl group are synthesized conveniently from reaction of α-fluoroalkyl ketones 1, aldehydes 2 or ethyl α-fluoroalkylacetates 3 with methyl (or ethyl) 2-sulfanylacetates 4. A possible reaction pathway is suggested.
synthesis - fluoroalkylthiophenes - cyclocondensation reaction - α-fluoroalkyl carbonyl compounds - alkyl 2-sulfanylacetate