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Synthesis 1997; 1997(3): 305-308
DOI: 10.1055/s-1997-1191
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A Short Synthesis of an Enantiopure Benzo[e]isoindolinone

Mark D. Andrews1 , Andrew G. Brewster2 , John Chuhan3 , Ashley J. Ibbett3 , Mark G. Moloney4 , Keith Prout3 , David Watkin3
  • 1The Dyson Perrins Laboratory, University of Oxford, South Parks Rd, Oxford OX1 3QY, UK
  • 2Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, SK10 4TG, UK
  • 3Chemical Crystallography Laboratory, University of Oxford, 9 Parks Rd, Oxford OX1 3PD, UK
  • 4The Dyson Perrins Laboratory, University of Oxford, South Parks Rd, Oxford OX1 3QY, UK, Fax +44(1865)275674; E-mail mark.moloney@dpl.ox.ac.uk
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Publication History

Publication Date:
31 December 2000 (online)

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An enantiopure benzo[e]isoindolinone is available by a sequence involving the reaction of a phenyl substituted tetramic acid with two equivalents of a stabilised phosphorane Ph3P=CHCO2R (R = Et or t-Bu).

tetramic acid - benzo[e]isoindolinone - synthesis - Wittig - Dieckmann

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