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Synthesis 1997; 1997(3): 290-292
DOI: 10.1055/s-1997-1180
short paper
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A Novel and Convenient Synthesis of 3-Methylfuran-2(5H)-one

Gerard H.L. Nefkens, Jan Willem J.F. Thuring, Binne Zwanenburg*
  • *NSR-Center for Molecular Structure, Design and Synthesis, Department of Organic Chemistry, University of Nijmegen, Toernooiveld, NL-6525 ED Nijmegen, The Netherlands, Fax +31(24)3652929; E-mail zwanenb@sci.kun.nl
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Publication Date:
31 December 2000 (online)

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3-Methylfuran-2(5H)-one (1a), a precursor of strigol and its analogues, is prepared in a highly efficient manner by a regiocontrolled alcoholysis of citraconic anhydride and subsequent reduction via the mixed anhydride 5c.

unsymmetrical cyclic anhydride - regioselective ring opening - reduction and lactone formation

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