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Synlett 1996; 1996(12): 1229-1230
DOI: 10.1055/s-1996-5726
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Asymmetric Catalytic Hydrosilylation of Ketones with Triethoxysilane Using a Chiral Binaphthol-Titanium Complex

Hironori Imma, Maki Mori, Takeshi Nakai*
  • *Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan, Fax +81(3)57342885
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Publication Date:
31 December 2000 (online)

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The asymmetric catalytic hydrosilylation of prochiral ketones with HSi(OEt)3 using (R)-BINOL-Ti(O-i-Pr)2 as a precatalyst is shown to proceed in excellent yields. Although the observed levels of enantioselectivity were moderate (up to 55% ee), an interesting phenomenon of ”enantioselective autoinduction” was observed.

binaphthol-titanium complex - asymmetric catalysis - hydrosilylation - enantioselective autoinduction

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