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Synlett 1996; 1996(11): 1036-1038
DOI: 10.1055/s-1996-5680
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1,2,6-Trisubstituted Tetrahydroisoquinoline Derivatives by Solid-Phase Synthesis

K. Rölfing, M. Thiel, H. Künzer*
  • *Research Laboratories, Schering AG-Berlin, Müllerstr. 170-178, D-13342 Berlin, Germany
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Publication Date:
31 December 2000 (online)

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An eight-step reaction sequence for simultaneous multiple synthesis of 1,2,6-trisubstituted 1,2,3,4-tetrahydroisoquinolines 17 on 2-hydroxyethyl polystyrene has been developed. Each target is comprised of a common fixed building block and four variable ones which are selected from three commercially available compound sets (ω-halogenated fatty acids, primary amines (2x), and acid chlorides). The assemblage of a prototype library featuring 24 discrete members serves to illustrate our protocol.

Multi-Step Solid-Phase Synthesis - Combinatorial Chemistry - Tetrahydroisoquinolines

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