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Synlett 1996; 1996(10): 1015-1017
DOI: 10.1055/s-1996-5651
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Direct Alkylation of 2-Acylamino- and 2-Aminopyrazines with Organolithium Reagents

Hideshi Nakamura* , Mihoko Aizawa, Akio Murai
  • *Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060, Japan, Fax +81(11)7462557, e-mail hnak@hucc.hokudai.ac.jp
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Publication Date:
31 December 2000 (online)

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Reactions of 2-acylamino- or 2-aminopyrazine with organolithium reagents in THF resulted in regioselective alkylation at C3 position in moderate yields.

2-aminopyrazine - organolithium - regioselective alkylation - bioluminescent imidazopyrazinone