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Synlett 1996; 1996(8): 743-744
DOI: 10.1055/s-1996-5537
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Enzyme-Catalyzed Synthesis of (S)-Chromanethanol and (R)-Mevalonolactone

Eisaku Mizuguchi, Tomiko Suzuki, Kazuo Achiwa*
  • *School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422, Japan, E-mail achiwa@ysz.u-shizuoka-ken.ac.jp
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Publication History

Publication Date:
31 December 2000 (online)

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(S)-Chromanethanol (10) and (R)-mevalonolactone (11) were synthesized from the commercially available prochiral triol (1). Enantioselective hydrolysis of the corresponding 1,5-dibenzoate (2) with lipases in organic solvent gave the optically active monobenzoate (-81%ee) which was then converted to the (S)-chromanethanol and (R)-mevalonolactone by chemical procedure.

3-Methylpentane-1,3,5-triol - Chromanethanol - Mevalonolactone - Lipase-catalyzed hydrolysis

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