PDF icon PDF herunterladen
Synlett 1996; 1996(6): 517-518
DOI: 10.1055/s-1996-5503
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Facile Synthesis of a Sterically Congested Amide: A Convenient Method of Steroidal 17β-Amide Synthesis from 17β-Carboxylic Acid and a Hindered Amine with 2,4,6-Triisopropylbenzenesulfonyl Chloride as a Condensing Reagent

Hitoshi Kurata, Koki Ishibashi, Koichi Kojima*
  • *Medicinal Chemistry Research Laboratories Sankyo Co. Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 2000 (online)

 als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik
Preview

Steroidal 17β-amides 2, 4, 6 were synthesized from the 17β-carboxylic acids 1, 3, 5 and sterically hindered amine in 88-100% yields using 2,4,6-triisopropylbenzenesulfonyl chloride as a condensing reagent. This method was successfully applied to the synthesis of sterically congested simple amide 8.

congested amide - condensation - triisopropylbenzenesulfonyl chloride - steroid