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Synthesis 1996; 1996(12): 1433-1434
DOI: 10.1055/s-1996-4408
short paper
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Selective Cleavage of tert-Butyl Esters in the Presence of tert-Butyl Ethers. Application to the Synthesis of tert-Butoxy Amino Acids

Arnold Trzeciak, Willi Bannwarth*
  • *PRPC, F. Hoffmann-La Roche Ltd., CH-4002 Basel, Switzerland
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Publication Date:
31 December 2000 (online)

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We report on the selective cleavage of tert-butyl esters in the presence of tert-butyl ether groups by using trimethylsilyl triflate. The method is especially useful for the synthesis of tert-butyl ethers of N-protected hydroxy amino acids which are valuable building blocks for peptide synthesis.

deprotection - trimethylsilyl triflate - tert-butyl ether of hydroxy amino acids

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