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Synthesis 1996; 1996(11): 1289-1290
DOI: 10.1055/s-1996-4380
short paper
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A Short Enantioselective Formal Synthesis of Methyl (S)-(-)-6,8-Dihydroxyoctanoate: A Key Intermediate for the Synthesis of R-(+)-α-Lipoic Acid

Maitreyee (Sarma) Bezbarua, Anil K. Saikia, Nabin C. Barua* , Dipak Kalita, Anil C. Ghosh
  • *Organic Chemistry Division, Regional Research Laboratory, Jorhat 785006, Assam, India, Fax +91(376)321158
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Publication Date:
31 December 2000 (online)

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A short enantioselective formal synthesis of methyl (S)-(-)-6,8-dihydroxyoctanoate starting from readily available 2-nitrocyclohexanone using a novel retro-Henry reaction is described.

R-(+)-α-lipoic acid - 2-nitrocyclohexanone - retro-Henry reaction

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