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Synthesis 1996; 1996(5): 594-596
DOI: 10.1055/s-1996-4256
short paper
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Chemoenzymatic Synthesis of Methyl(6S)-(-)-6,8-Dihydroxyoctanoate: A Precursor to (R)-(+)-α-Lipoic Acid

Y. R. Santosh Laxmi, D. S. Iyengar*
  • *Organic Division-II, Indian Institute of Chemical Technology, Hyderabad-500007, India
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Publication Date:
31 December 2000 (online)

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A short synthetic sequence for the preparation of methyl (6S)-(-)-6,8-dihydroxyoctanoate, the precursor to (R)-(+)-α-lipoic acid is described starting from (2S)-(+)-2-(tetrahydro-2-furyl)ethanol.

Synthesis of the diol ester 11 S from (2S)-(tetrahydro-2-furyl)ethanol obtained by a lipase mediated resolution

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